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Study details
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Neurostimulation Versus Therapy for Problems With Emotions

Duke University
NCT IDNCT05712057ClinicalTrials.gov data as of Apr 2026
Target enrollment

240

Study length

about 4.1 years

Ages

18–55

Locations

1 site in NC

What this study is about

Researchers are testing whether a single session of neurostimulation, combined with emotion regulation training, helps people manage their emotions better than just using the neurostimulation alone. The trial also aims to find out how brain changes relate to who responds best to this type of treatment.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Participate in Cognitive Restructuring
  • 2.Participate in Emotional Awareness Training
  • 3.Use Repetitive Transcranial Magnetic Stimulation (rTMS)
  • +1 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Primary: High Frequency Heart Rate Variability (HF-HRV) during regulation blocks during the neurostimulation day, Time to return to Heart Rate (HR) baseline measured during regulation period

Secondary: Self Efficacy with Emotion Regulation (PROMIS-SEME)

Devices

therapeutic

Body systems

Psychiatry / Mental Health