Skip to content
Study details
Enrolling now

Pimavanserin for Insomnia in Veterans With PTSD

VA Office of Research and Development
NCT IDNCT05441280ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

60

Study length

about 3.5 years

Ages

18–64

Locations

1 site in TX

What this study is about

This trial is testing whether pimavanserin helps with insomnia in veterans who also have post-traumatic stress disorder (PTSD). Participants will receive either pimavanserin or a placebo at bedtime for 8 weeks, and their sleep quality will be compared before and after treatment. The goal of it is to understand if pimavanserin can help treat PTSD-related insomnia.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Placebo
  • 2.Take pimavanserin

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Oral

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

pimavanserin

Drug routes

oral (Oral Capsule)

Endpoints

Primary: Insomnia Severity Index (ISI)

Secondary: PTSD Checklist for DSM-5, Pittsburgh Sleep Quality Index (PSQI)

Body systems

Psychiatry / Mental Health