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Study details
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Explosive Synchronization of Brain Network Activity in Chronic Pain

University of Michigan
NCT IDNCT04606095ClinicalTrials.gov data as of Apr 2026
Target enrollment

150

Study length

about 5.3 years

Ages

19–74

Locations

1 site in MI

What this study is about

Researchers are testing whether explosive synchronization and its treatment with non-invasive brain stimulation can help people with fibromyalgia. The trial will measure brain activity, connectivity, and response to pain in both healthy volunteers and people with fibromyalgia. It also involves a longitudinal assessment of fibromyalgia patients undergoing HD-tDCS or ES HD-tDCS.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.EEG
  • 2.Neuroimaging EEG/fMRI (Aim 1)
  • 3.Neuroimaging EEG/fMRI (Aim 3)
  • +2 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Secondary: Aim 1: Insular Glx (glutamate + glutamine) using proton magnetic resonance spectroscopy obtained at Visit 2, Aim 1: Resting brain functional connectivity using functional magnetic resonance imaging obtained at Visit 2

Procedures

diagnostic, imaging

Devices

therapeutic, diagnostic

Body systems

Musculoskeletal