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Study details
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Cladribine and Rituximab in Treating Patients With Hairy Cell Leukemia

M.D. Anderson Cancer Center
NCT IDNCT00412594ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

150

Study length

about 23 years

Ages

18+

Locations

1 site in TX

What this study is about

This trial is testing the effects of cladribine and rituximab, a treatment combination, on patients with hairy cell leukemia. Cladribine is a drug that stops cancer cells from growing or spreading, while rituximab helps the immune system fight cancer. The goal is to see how well this combination works in treating hairy cell leukemia.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Laboratory Biomarker Analysis
  • 2.Receive Rituximab
  • 3.Take Cladribine

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IVInjection / IV

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

cladribine, rituximab (Monoclonal antibody; targets CD20 on B-cells to destroy them)

Drug routes

injection, intravenous, infusion

Endpoints

Primary: Efficacy of rituximab on prolongation of event-free survival, Efficacy of rituximab on prolongation of overall survival, Monitoring the related toxicity for the therapy Grade 3-4

Body systems

Oncology